What is the main cause of eczemaEczema is the most common form of chronic dermatitis, a non-infectious skin condition characterized by an itchy rash. Commonly, across the literature, it is referred to as atopic dermatitis (AD) as well. Typically, it affects children and the situation gets better as time goes by, but adults can suffer from it as well. However, when it comes to the causes, there is no straightforward answer to explain these. By what we know about it so far, the most accurate answer would be – it is caused by a combination of genetic and environmental factors (basically, this means it is caused by something that’s written in the patient’s genetic code and something in his or her environment). However, giving that this answer can hardly satisfy the curiosity of people interested in the condition, we will discuss it in more detail and provide a broader perspective on the perplexity of eczema origin.

The roots are deep within the DNA 13

Although the pathophysiological mechanisms that cause eczema are pretty well described, their exact background remains to be a subject for academic debate. There are two widely accepted hypotheses – the first one concerns the imbalance in the immune system, and the second one concerns a defect in the skin barrier. The definitive answer to why eczema happens is still not found, but the two hypotheses offer a reasonable explanation. Also, they shouldn’t be taken as mutually exclusive but rather as points of view that complement each other.

The imbalance in the immune system hypothesis

The theory argues that the eczema results from an imbalance in the T cells production – in particular, in people with eczema, there are more T-helper 1 and T-regulatory cells (subtypes of T cells) than there should be. As a result, the amount of interleukins (substances that promote inflammatory response) is increased, so is the intensity of inflammation in the affected areas of the body.

The skin barrier hypotheses

The theory is a newer one and argues that individuals with mutations in the filaggrin gene more often develop eczema than those without the mutation. The filaggrin (filament aggregating protein) binds cells in the upper layer of the skin (referred to as epidermis) together and seals the tiny cracks between them. Filaggrin minimizes the water loss through the skin and penetration of the allergens from the environment (the size of the allergens varies – from small inorganic to large organic molecules or even microorganisms). In some people with the mutation, the production of filaggrin drops critically low, so the skin barrier doesn’t function as it should. The skin becomes more permeable for water (increased water loss), allergens and microorganisms.

The toll on health goes beyond the skin surface

Let’s take a pause from eczema causes here and briefly discuss the phenomenon known as “The Atopic March.” Our immune system works as a whole – defects in the execution of its functions reflect themselves on the whole body more often than not. Eczema is a skin condition, but the same genetic factors that lie in its background also affect other regions of the body. “The Atopic March” describes a temporal sequence of conditions that develop on the terrain of inadequate immune response seen in patients with eczema. The flaw mentioned above in the T-helper

lymphocyte function also can cause food allergies, asthma or allergic rhinitis. The eczema kicks in first and, in the early years of life, is often followed by the rest of the atopic cascade. The importance of this phenomenon lies in the fact that a timely treatment of eczema can reduce the severity of or prevent in temporary conditions that follow it.

Environmental factors

As mentioned earlier, the leading cause of eczema is a combination of genetic and environmental factors. Not all people with the “right genetic code” develop the condition. Eczema happens only if all or the majority of contributing factors align, creating a perfect storm. In this section, we’ll take a look at contributing environmental factors. The prevalence (the number of cases of a disease present in a particular population in a given time) of eczema has increased in the past few decades at a pace that changes in gene pool cannot explain. So, the increase in prevalence is explained by changes in environmental factors. At this moment, we can’t tell for sure what those factors are. Still, the growing body of scientific evidence suggests that exposure to dust mites, various allergens, infections, irritants and antibiotics increases the prevalence of eczema 1.

Hygiene Hypothesis 

The theory was introduced to the public back in 1989, and it suggests that the main cause of increased eczema prevalence may be the development and “sanitization” of society. The theory argues that the lack of adequate stimulation of the immune system in early life (children that are “too clean”) and failure of maintaining balanced gut flora in adulthood (antibiotics in food) are triggering factors in the pathogenesis of eczema. Furthermore, the hygiene hypothesis explains the rapid rise in prevalence among smaller, wealthier and more educated families in comparison with larger families and those attending a nursery.

The bottom line is that exposure to some pathogens in early life, as well as the timing of exposure, play an essential role in the pathogenesis of eczema. However, some pathogens may trigger the condition; for example, measles infection increases the risk of the disease.

References : 2,3,4,5

Irritants 6,7,8,9,10,11,12

Soap acts as an irritant. It causes skin dryness, increases its pH, and transepidermal water loss. Several studies have shown that exposure to soap is in relation to increased eczema prevalence and that removal or avoidance of such chemicals reduces its prevalence.
Some studies have shown that eczema prevalence is increased in areas with harder water, but in recent years this hypothesis has been rejected. Namely, the increased hardness of water requires increased use of soap, so the scientific community accepted the use of irritants as the cause of eczema rather than the water harness.
The avoidance of irritants early in life is vital as a preventive measure – once the condition establishes, exclusion of those chemicals do not affect further development of the disease (eczema, followed by atopic march).

So, what is the main cause of eczema?

After this discussion, it is essential to underline that eczema is a multifactorial disease. Its causes are not yet fully understood, and some claims about it are still wrapped in a veil of controversy. However, here are some important takeaway notes:
– The condition is a multifactorial disease caused by a combination of genetic and environmental factors.
– The genetic mutations in people with eczema affect not only the skin but potentially other organ systems, primarily respiratory organs. Eczema is often only the first in a cascade of health issues that arise from altered genes.
– Restriction from exposure to the microbes in the environment is in association with the increased prevalence of eczema, but some infective agents may increase the chance of disease establishment.
– Once the condition establishes, it is impossible to reverse the process, but it tends to milden or completely disappear during puberty.
– Exposure to skin irritants, soap in the first place, plays an important role in the pathogenesis of the disease.

Reference list

1. McPherson T. (2016). Current Understanding in Pathogenesis of Atopic Dermatitis. Indian journal of dermatology, 61(6), 649–655
2. Strachan DP. Hay fever, hygiene, and household size. BMJ. 1989;299:1259–60.
3. Williams HC. Atopic eczema – Why we should look to the environment. Br Med J. 1995;311:1241–2.
4. Flohr C, Yeo L. Atopic dermatitis and the hygiene hypothesis revisited. CurrProblDermatol. 2011;41:1–34.
5. Hesselmar B, Sjöberg F, Saalman R, Aberg N, Adlerberth I, Wold AE. Pacifier cleaning practices and risk of allergy development. Pediatrics. 2013;131:e1829–37.
6. MJ Cork. The importance of skin barrier function. Taylor & Francis J Dermatological Treatment. 1997.
7. McNally NJ, Williams HC, Phillips DR, Smallman-Raynor M, Lewis S, Venn A, et al. Atopic eczema and domestic water hardness. Lancet. 1998;352:527–31.
8. McNally NJ, Williams HC, Phillips DR. Atopic eczema and the home environment. Br J Dermatol. 2001;145:730–6.
9. Font-Ribera L, Gracia-Lavedan E, Esplugues A, Ballester F, Jiménez Zabala A, Santa Marina L, et al. Water hardness and eczema at 1 and 4 y of age in the INMA birth cohort. Environ Res. 2015;142:579–85.
10. Thomas KS, Dean T, O’Leary C, Sach TH, Koller K, Frost A, et al. A randomised controlled trial of ion- exchange water softeners for the treatment of eczema in children. PLoS Med. 2011;8:e1000395.

11. Simpson EL, Chalmers JR, Hanifin JM, Thomas KS, Cork MJ, McLean WH, et al. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy ClinImmunol. 2014;134:818–23.
12. Harris JM, Williams HC, White C, Moffat S, Mills P, Newman Taylor AJ, et al. Early allergen exposure and atopic eczema. Br J Dermatol. 2007;156:698–704.
13. Thomsen S. F. (2014). Atopic dermatitis: natural history, diagnosis, and treatment. ISRN allergy, 2014, 354250.

Vitiligo Treatment Program
Treatment of Psoriasis

Treatment of Alopecia Areata Universalis


CubaHeal Research Department:

head and neck cancer90 % of head and neck cancers are mostly squamous cell carcinomas. These carcinomas include nasopharyngeal cancer, nasal cavity, paranasal sinus cancer, oral and oro pharyngeal cancer, laryngeal cancer, hypo pharyngeal cancer and salivary gland cancer. As carcinomas their name indicates they are malignant tumors.

Oral and oro pharyngeal, laryngeal, hypo pharyngeal and salivary gland cancers are included in oral cavity cancers which are all squamous cell carcinomas and salivary gland carcinomas are adenocarcinomas. 95% of oral cavity cancers are squamous cell carcinomas. This aggressive epithelial malignancy is the sixth most common neoplasm in the world today .The overall long term survival rate has been less than 50% for the most past years. Multiple primary tumours will be present in initial diagnosis .These multiple primary tumours develop independently as a result of years of chronic mucosal epithelium exposure to carcinogens such as alcohol or tobaccos .Oropharynx cancer is due to mutations in TP53 gene and genes that regulate the differentiation of squamous cells such as p63 and notch1. Squampous cell carcinoma can arise anywhere in the oral cavity .The most common locations are the ventral surfaces of the tongue floor of the mouth lower lip soft palate and gingiva. These tumors
appear as raised firm pearly plaques. Republic of CUBA has succeeded in combating these cancers.

Salivary gland adenocarcinomas include pleomorphic adenoma and muco epidermis carcinoma. Pleomorphic adenomas are painless slowly growing mobile discrete masses. They represent about 60% in parotid and are less common in submandibular glands. While muco epidermoid carcinoma are composed of variable mixture of squamous cells, mucus secreting cells and intermediate cells.

Nasal cavity and paranasal sinus cancers. Squamous epithelial cells of the normal nasal cavity or sinuses can become squamous cell carcinomas. This is the most common type of cancer in the nasal cavity and Paranasal sinuses. Apillomas are warts that can grow inside the nasal cavity or paranasal sinuses and destroy healthy tissue. They usually have a bumpy surface. Papillomas are not cancer, but sometimes a squamous cell carcinoma will start in a papilloma .Republic of CUBA is trying to cure these carcinomas. Different drugs are given in CUBA and 24 hour observation of a patient is done.

Treatment by Cuba health centre.

The Republic of Cuba is in the forefront in battling these cancers. Cuba is taking measures to stop these carcinomas. Available Treatments are surgery radiations and chemotherapy in combination with immunotherapy. The treatment is based on the stage of cancer and on the health of the patient.

The program is carried by guiding the patient properly and thoroughly. If the cancer has not metastasized and its size is small, we can do surgery and also can treat him through radiations. Some drugs will also be given .Chemotherapeutic agents will be given according to their effects and by keeping in mind the condition of individual because chemotherapeutic agents also destroy the normal cells. Treatment procedure is mostly same in all the cancerous patients. But it depends upon the severity and stage of cancer In CUBA by the following method we treat cancer

  • First of all a proper medical check-up is done .or we can say pre-application medical
    check-up is applied.
  • Anti-cancerous drugs are given.

These drugs include cyclophosphamide 200mg. This is a nitrogen mustard agent.it inhibits DNA function and its synthesis. It is given for breast cancer, ovarian cancer and chronic lymphocytic lymphoma. In republic of CUBA this drug is given with proper dosage and according to the condition, otherwise every drug has some adverse effects. This drug is given for 15 days and when further treatment starts.

Another drug which is given in republic of CUBA is NIMOTUZUMAB it is also called CIMAher EGF. It is given for head and neck cancers in combination with radiotherapy and chemotherapy. 24 Vials are given for 6 weeks treatment. It should be given with precautions otherwise nausea tremors and chills can develop.It is given in IV form.

The induction phase last six weeks corresponding to the 24 vials of the drug. The first dose will be given in republic of Cuba , and next dose he can take himself in CUBA or any other country.

There are many drugs available for the chemotherapy. These drugs are bortizomib imatinib, antimetabolites, vincristine, and etoposide. Each drug first dose is given in CUBA. Patient is monitored. If this drug found successful then second dose of the drug he can take himself.


Surgeries are also performed. That involves dissecting of the whole infected part. If less part is infected then a small part is dissected but mostly if small part is infected we took out large part even the whole part is not infected as a precaution.

These surgeries involve Total glossectomy semi glossectomy semi glossectomy partial glossectomy, trans maxillary glossectomy with neck dissection.

Total glassectomy : It is performed for the tongue .if whole tongue is affected whole tongue we be cut down so that the tumour does not metastasize. This is done in republic of CUBA with proper care.

Semi-glossectomy : It is the removal of half the tongue. This can also be done in republic of CUBA with proper care. If half tongue is not infected and other half is infected so we can perform partial dissection with proper care. We will cut half tongue if there is no chance of spreading this tumour to the other half.

Trans maxillary glassectomy with neck dissection. When cancer in the oral cavity is spread to the lymph nodes in the neck so removal of these lymph nodes is necessary because there are many lymph nodes are present in different sites of body. So cancer can spread to the different organs through lymph nodes which will be worst condition. Neck surgery is also performed in republic of CUBA. These include partial and modified neck dissections. Radical neck dissections are also performed.in which few or all lymph nodes are removed. There are also some maxillary and larynx medical programs in republic of CUBA in which partial or full dissection of the affected region is performed.

So CUBA is making a great progress in the treatment of cancer.



Cuba had the honor to host the first international conference regarding autism and inclusion in 2013. Island’s extraordinary efforts to understand, recognize and manage the condition in it’s early stages highlight the prestige and excellence of Cuba’s autism management. Cuban physicians represent global subject-matter-experts in the field of autism spectrum disorder (ASD). Cuba strives to find the best possible solutions for individuals suffering from ASD through the development of specialized ASD centers that focus on ASD treatment and inclusion of families within the society – of course, absolutely cost-free.

ASD represents a complex condition requiring multidisciplinary approach – a burden for profit- based healthcare systems. The fact that the management of ASD has been assessed as costly best illustrates the difficulties of western systems to properly address the issue of growing incidence of ASD. Waiting lists, inefficiency, high prices are the characteristics of profit-based healthcare systems that often result in inadequate management of those requiring prompt and intensive treatment. Cuba has developed a sustainable program for the management of individuals suffering from ASD focused on meeting the needs of each child.

Cuba offers a carefully tailored program for individuals suffering from autism spectrum disorder (ASD). The main goal of this program is to improve the child’s learning capabilities and reduce the symptoms of ASD. Overall, the program aims to boost the development capacity of each child with ASD. As a result, a visible improvement is seen in the child’s physical and mental abilities, due to the specific nature of the program design that is specifically tailored to meet the needs of each child individually. The program offers a peaceful and comfortable treatment environment and expert medical attention, which is very relevant for achieving the favorable treatment outcome. The facility is equipped with services and amenities such as cable TV, internet, pool, sauna, gym, pharmacy, and laundry services.

Program description

The program duration is 38 days. During this period, a set of activities is performed that may be divided into two main stages – evaluation and treatment. A detailed description of each phase is given below.

Stage 1 – Evaluation

During the evaluation phase, the information regarding the ASD nature of each child is obtained through consultation with specialists, laboratory and clinical investigations, as well as specific assessments necessary for evaluation and staging of the disease.

The initial steps in the evaluation phase include consultations with the team of experienced specialists in order to plan and tailor the comprehensive treatment and rehabilitation program for each child. This includes assessments performed by pediatricians, neuro-pediatricians, child psychologists, genetics specialists, logophobia specialists as well as otorhinolaryngologists. Furthermore, detailed laboratory investigations are required for disease evaluation and assessments. Biochemistry panel includes measurements of urea, creatinine, serology investigations, urine metabolic testing, complete blood count, sedimentation rate, blood glucose level, including but not limited to liver function tests.

Following initial testing, complex assessments are performed in order to get the clear picture regarding disease nature and severity. The assessments are performed by highly experienced subject-matter-experts and include logopedic evaluation, neuropsychologic assessment, Brunet-Lezine scale evaluation, as well as psychotherapy assessment and evaluation. Additionally, during the assessment period imaging studies may be performed such as brain MRI, evoked potential studies, EEG etc.

Once all the information has been gathered and a treatment plan has been tailored, the findings and possible management options are discussed with the family. The duration of this phase is dependable on the nature of the underlying disease as well as the child’s abilities to adapt to the new environment. Approximately, it takes no longer than 10 days in order to complete the evaluation and tailor the specific treatment.

Stage 2 – ASD Management

ASD represents a complex disorder requiring multidisciplinary and individual treatment approach for each child. This program offers multiple treatment modalities including equine therapy, sensorial stimulation techniques, occupational therapy, language therapy, ozone treatment as well as trans-cranial electric stimulation, which has been proven useful in hyperkinetic patients. Treatment is conducted by highly experienced experts with the constant involvement of parents.
The focus is on speech therapy that lasts for 20 days and involves both therapists and parents. This treatment modality lasts approximately 20 days and is conducted each day excluding Sundays and public holidays. Depending on the child’s ability to accept the treatment approach, initial sessions may last from 20 minutes to one hour. Protocol for conducting the therapy is tailored based on the individual characteristics of each child. It is strongly advised for the child to continue this treatment approach at home, once the language therapy is finished since this will ensure the long-
lasting results in the future.

Occupational therapy will last approximately 30 days where the intensive treatment will aim to reduce neurological, mental and physical barriers of each child with ASD. This program allows a child to develop and maintain self-care activities, increases the overall productivity and enables a child to participate in leisure activities. The intensive treatment protocol is comprised of two treatment sessions during the day (in the morning and in the afternoon) approximately lasting for an hour or longer. The responsiveness of a child is stimulated by various methods including images projection, object identification, interactive and didactic games, palpation exercises as well as equine therapy.

At the end of each treatment, a detailed report is issued to parents with all of the activities performed at the site including detailed expert recommendations for further treatment and rehabilitation.

In short words

CubaHeal Medical is a global organization specialized in facilitating medical treatments, medical education, in addition to patient and student care in the Republic of Cuba. CubaHeal is a loyal supporter of the Republic of Cuba, the Cuban people, the Cuban revolution, and the Cuban revolutionary leadership.


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